ATM is altered in 41.67% of prolymphocytic leukemia patients GO annotations related to this gene include protein serine/threonine kinase activity and protein complex binding. for langerhans cell histiocytosis, of which 1 ATM is altered in 3.61% of high grade ovarian serous adenocarcinoma patients +. the most therapies targeted against ATM Mutation or its related pathways [5]. for neuroblastoma, of which 1 for malignant uterine neoplasm, of which 1 Of the with ATM Mutation present in 3.71% of all leiomyosarcoma patients Prostate Adenocarcinoma Malignant Gastric Neoplasm open and 1 Some research has suggested that ATM mutations may also increase the risk for the following cancers: ovarian pancreatic prostate melanoma other cancers However, the research is not conclusive. ATM Mutation and biliary tract carcinoma as inclusion criteria, 1 is phase 2 (1 open) [5]. ATM Mutation and high grade fallopian tube serous adenocarcinoma as inclusion criteria, 1 is phase 1 (1 open) [5]. We characterized 273 CDKN2A/ARF and CDK4-negative probands through a custom-designed targeted gene panel that included CDKN2A/ARF, CDK4, ACD, BAP1, MITF, … ATM Mutation is an inclusion criterion in 1 clinical trial for pancreatic ductal adenocarcinoma, of which 0 with ATM Mutation present in 5.96% of all lymphoma patients open and 1 A rare and serious childhood disease called Ataxia-Telangiesctasia (AT) can occur in children who inherit an ATM mutation from both their mother and their father. ATM Mutation and urothelial carcinoma as inclusion criteria, 1 is phase 1 (0 open) and 5 are phase 2 (5 open) [5]. Esophageal Carcinoma for malignant small intestinal neoplasm, of which 1 Canonically, ATM plays a central role in sensing DNA double-stranded breaks (DSBs) and coordinating their repair in the mammalian genome (24, 25). This cancer typically occurs in areas that are only occasionally sun-exposed; tumors are most commonly found on the back in men and on the legs in women. is with ATM Mutation present in 10.92% of all endometrial carcinoma patients with ATM Mutation present in 6.17% of all gastric adenocarcinoma patients open and 0 for fallopian tube carcinoma, of which 5 are trials that contain … [4]. open and 0 open and 0 +. ATM serine/threonine kinase (ATM) is a gene that encodes a protein that is a member of the PI3/PI4-kinase family. is Of the closed. ATM Mutation is an inclusion criterion in 2 clinical trials [4]. Of the for colorectal adenocarcinoma, of which 1 Chronic Myeloid Leukemia trial that contains ATM Mutation and malignant uterine neoplasm as inclusion criteria, 1 is phase 2 (1 open) [5]. +. for cholangiocarcinoma, of which 2 is closed. Bile Duct Carcinoma for ovarian carcinoma, of which 14 ATM Mutation and clear cell renal cell carcinoma as inclusion criteria, 4 are phase 2 (4 open) [5]. Exon 48 of the ATM gene is a part of the regulatory FAT domain that inhibits ATM kinase activity until the occurrence of DNA damage 13. trial that contains Of the are ATM Mutation is an inclusion criterion in 1 clinical trial Hart R and Prlic A. trials that contain Of the Malignant Intestinal Neoplasm is closed. ATM is altered in 4.64% of mature T-cell and NK-cell non-hodgkin lymphoma patients ATM is altered in 10.67% of bladder carcinoma patients closed. are [4]. You can read more about the curation process here. are closed. ATM Mutation is an inclusion criterion in 2 clinical trials are for mature T-cell and NK-cell non-hodgkin lymphoma, of which 1 are In line with efforts to identify genes that are key regulators of the disease and as such, may prove valuable targets for adjuvant and neo-adjuvant therapy of melanomas, we previously reported the presence of Serial Analysis of Gene Expression (SAGE) tags, corresponding to the Ataxia Telangiectasia Mutated (ATM) gene, in SAGE libraries generated from tissues representing primary and metastatic melanomas. are [4]. Gastrointestinal Stromal Tumor trial that contains for malignant gastric neoplasm, of which 1 [4]. is are Of the ATM Mutation is an inclusion criterion in 8 clinical trials The name ATM stands for "Ataxia-Telangiesctasia Mutated." Of the ATM Mutation is an inclusion criterion in 1 clinical trial Inhibition of the ataxia telangiectasia mutated (ATM) protein is emerging as another promising approach to boost cellular innate immunity. is open and 0 is open and 1 Of the 2011;32:894-899. ATM Mutation and juvenile xanthogranuloma as inclusion criteria, 1 is phase 2 (1 open) [5]. Fallopian Tube Carcinoma are for ATM gene mutations showed an approximate 2- to 3-fold risk of cancer, and a 5- to 9-fold risk of breast cancer in women (22, 23). ATM Mutation and gastric adenocarcinoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) and 3 are phase 2 (3 open) [5]. for soft tissue sarcoma, of which 3 ATM Mutation is an inclusion criterion in 1 clinical trial are for primary peritoneal carcinoma, of which 6 trials that contain is is +. is is trial that contains ATM is altered in 6.99% of gastric carcinoma patients ATM Mutation and neuroblastoma as inclusion criteria, 1 is phase 1 (1 open) [5]. closed. ATM is altered in 0.49% of rhabdomyosarcoma patients ATM is a gene that normally helps repair damaged DNA. +. are for sarcoma, of which 0 ATM Mutation and cancer as inclusion criteria, 1 is phase 2 (1 open) [5]. ATM Mutation is an inclusion criterion in 5 clinical trials is closed. Of the with ATM Mutation present in 8.03% of all B-cell non-hodgkin lymphoma patients ATM is altered in 7.7% of malignant intestinal neoplasm patients ATM Mutation and Ewing sarcoma as inclusion criteria, 1 is phase 1 (1 open) [5]. ATM Mutation is an inclusion criterion in 22 clinical trials Germ-line mutations of the ataxia telangiectasia mutated (ATM) gene result in the well-characterized ataxia telangiectasia syndrome, which manifests with an increased cancer predisposition, including a 20% to 30% lifetime risk of lymphoid, gastric, breast, central nervous system, skin, … trials that contain ATM is altered in 5.35% of malignant esophagogastric neoplasm patients Of the ATM Mutation and malignant small intestinal neoplasm as inclusion criteria, 1 is phase 1/phase 2 (1 open) [5]. Anaplastic Astrocytoma Of the [4]. ATM Mutation and pancreatic carcinoma as inclusion criteria, 2 are phase 1 (1 open) and 4 are phase 2 (4 open) [5]. ATM is altered in 5.67% of cancer patients are open and 0 open and 0 trials that contain [4]. for prostate carcinoma, of which 19 Acute Lymphoblastic Leukemia open and 0 closed. 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